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For instance, computer mice with an anomaly for nNOS display regular mating behavior and erectile function; eNOS is upregulated in these computer mice which may compensate for interrupted NO manufacturing [Burnett et al., 1996]<br>If alleviative treatment is not feasible because of an absence of existing restorative drugs or treatments, by definition a persistent therapy concept (long-term treatment) is focused on. Many diseases of people, such as arterial high blood pressure or diabetic issues mellitus, are considered chronic diseases and are treated with chronic restorative concepts. Chronic therapy ideas aim to alleviate signs and, preferably, to slow down the development of the underlying disease and prevent adverse repercussions of the underlying illness.<br>In the realm of cardiovascular disease treatment, the exploration and advancement of targeted delivery systems hold promise for changing exactly how we approach heart failure treatment. 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